Usually, your NeuroEndoMetabolic (NEM) Stress Response does its work behind the scenes to help you cope with stress, and then it shuts down once your stress levels go down again. Your relaxed in stressful situations, sleep well, are fun to be around, and enjoy high adrenaline activities. Your email address will not be published. On the flip side, if your COMT gene is too fast, you may find it difficult to build up enough stress to motivate you to get a job done or stay focused. The extra virgin olive oil phenolic oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase. Catecholaminergic gene variants: contribution in ADHD and associated comorbid attributes in the eastern Indian probands. As the A allele form of COMT displays reduced methylation activity its methyl donor source (methionine) builds up. 
Get lots of hugs! Talk to your doctor about a cheek swab test. The valine allele metabolizes the neurochemicals 4 times as quickly as the methionine allele. You may also like these articles on genetics, Poor methylation, MTHFR and Histamine Intolerance, Symptoms of a PEMT Gene Mutation and Choline Deficiency, https://pubmed.ncbi.nlm.nih.gov/12197785/, https://pubs.acs.org/doi/pdf/10.1021/jf000026%2B. 
Its actually quite simple to test for COMT and MTHFR gene mutations. In people with a COMT mutation, their body finds it challenging to remove catechols. ~ Printable topic summary reports. (2019). Oxalic acid depletes B6. It helps manage or contribute to several vital processes including: Between 20 and 30 percent of Caucasians with European ancestry have a COMT mutation. Potatoes (all, even sweet potatoes) Coffee. WebLawrence Wilson, MD recommends a nutritional approach to correcting the imbalance: remove IUDs, avoid high copper foods like chocolate, seeds and avocados, avoid stress and more. A higher risk of violence has been found in schizophrenics carrying the methionine allele (associated with high epinephrine).8 Both homozygous genotypes have been associated with PTSD, in contrast with the heterozygous genotype.9, Genetic inheritance should be only the first part of our analysis. https://doi.org/10.1080/03602532.2016.1258075 It is vital that you include healthy eating, good sleep, movement and avoid excessive environmental toxins. Clinicians often suggest that those with the rs4680 A/A genotype (slow COMT) avoid going overboard with foods and supplements considered methyl donors. However, you still need to stay healthy overall and limit oxidative damage in your body by eating a healthy balance of plant nutrients. Nothing stated or posted on this web site or available through any services offered by ND News & Review, LLC, are intended to be, and must not be taken to be, the practice of medicine. region: "na1", In terms of the why this occurs, it is yet again just random gene mutation here. * Dr. Lam in our products and services refers to Dr. Michael P. Lam, MD, founder of DrLam.com and DrLamCoaching.com. SAMe is available in supplement form, but it is also essential to help the body make its own SAMe by eating foods high in B vitamins, especially B12, folate, and B2. In people with a COMT mutation, their body finds it challenging to remove catechols. Even healthy changes can increase your stress levels and strain your NEM stress response systems, so you need to be careful. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Focusing primarily on epinephrine as our major example, if COMT is not metabolizing effectively (the result of carrying a polymorphism in the gene), epinephrine will build up, potentially leading to aggression, anxiety, anger, etc. This means you might experience higher than usual levels of these chemicals as well as the metabolites they help create. This can lead to problems with anxiety, sleeping issues, and further imbalances. Malloy-Diniz LF, Lage GM, Campos SB, et al. Monoamine oxidase (MAO) converts both metanephrines to VMA. This can cause a range of symptoms such as: Problems with the COMT gene can also cause low or high dopamine levels. This is even more important if you have AFS and need to find better ways to manage your condition. Be on the alert for paradoxical reactions. The most common variant in this context was found to be defined by an amino acid substitution of methionine (Met) in place of valine (Val) at position 158 (Val158Met). Sak, K. (2017a). Similarly the T allele of C186T is always present when the A allele of G472A is. 
https://doi.org/10.1080/03602532.2016.1258075 MTHFR activates 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF). Funny enough, my husbands grandfather made the paper once with his eggplants nose, and out of the weird mutant vegetables, this one is the most funny to me. Association of the catechol-o-methyltransferase gene polymorphisms with Korean autism spectrum disorders. Colzato LS, van den Wildenberg WP, Hommel B. Cognitive control and the COMT Val158Met polymorphism: genetic modulation of videogame training and transfer to task-switching efficiency. Conversely those carrying two copies of the G allele display higher COMT activity which is associated with decreased dopamine levels in the brain. Polymorphisms in catechol-o-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease. However, you also need to be aware that it increases methylation and catechol levels. C186T was often therefore used as a proxy for G472A due to difficulties with its analysis. Avoiding these foods will help to take the load off a slow COMT gene. Alcohol, since it can trigger a dopamine release in your body. Pharmacogenetics of modafinil after sleep loss: Catechol-O-methyltransferase genotype modulates waking functions but not recovery sleep. JNCI: Journal of the National Cancer Institute, 111(7), 684694. This means that the gene that produces an enzyme to break down certain substances and toxins doesnt work the way it should, causing a range of health, hormone, and stress-related issues. However, it is important to note that the interaction between genetics and behaviour is very complex. However, modern consumer genetic testing kits are able to accurately differentiate between G472A allele making assessment of C186T redundant. WebCatechol-O-methyltransferase (COMT) is an enzyme which inactivates neurotransmitters such as dopamine and epinephrine in the brain, and is encoded for by the COMT gene 1. Journal of Molecular and Cellular Cardiology, 157, 3144. Dr. Gina Leisching holds a BSc in Functional Human Biology, and Honours degree in Physiological Sciences, as well as a doctorate in human physiology from Stellenbosch University, South Africa. Carriers are therefore sometimes termed Worriers 9. Of course, most of these Clinicians often suggest that those with the rs4680 A/A genotype (slow COMT) avoid going overboard with foods and supplements considered methyl donors. In vitro research has shown that estrogenic plasticizers, such as bisphenol A (BPA), benzyl butyl phthalate (BBP), and di-n-butyl phthalate (DBP) inhibit COMT activity, which leads to higher catecholamine levels.10 Mercury toxicity also inhibits COMT activity through inhibition of S-adenosylmethionine (SAM), a coenzyme for COMT.11. The COMT enzyme plays an essential role in maintaining neurotransmitter levels at the right amount. Calcium-d-glucarate helps to support the metabolism of estrogen via the glucuronidation pathway. You should eat a balanced diet rich in natural folate from food, but it is very difficult to get the recommended amount of folate from food alone. https://doi.org/10.3390/nu12082336 The information on this website, related social media accounts and websites, and email newsletters is for educational purposes only. Wang, L.-J., Lee, S.-Y., Chen, S.-L., Chang, Y.-H., Chen, P. S., Huang, S.-Y., Tzeng, N.-S., Chen, K. C., Lee, I. H., Wang, T.-Y., Yang, Y. K., & Lu, R.-B. A step by step guide is available on the Advanced Functional Medicine website to easily arrange your genome test. Adopting strategies to lower your stress levels will decrease your bodys demand for cortisol and lower adrenal activity. Slow COMT activity may mean that you dont have enough SAMe or too much homocysteine. SAMe then supports the COMT gene to help metabolize estrogen and stress neurotransmitters. Understand that these are metabolic pathways. You can also do COMT gene testing with the Strategene DNA test kit which is the best at home genetic testing kit I have come across! Someone with a dirty slow COMT gene is likely to feel anxious and moody. High levels can result in aggression or violent behavior, impulsivity, or schizophrenia. This is another strategy that will benefit AFS as well by helping to limit blood sugar spikes and giving your body the nutrients it needs to function properly. Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration. Systems pharmacogenomics gene, disease, drug and placebo interactions: A case study in COMT. Upload raw genetic data for nutrition and SNP insights. Maca Root: Research-backed Benefits and How It Works, Fluoride: Understanding Its Effects on Health, Nickel Allergy: Genetics, causes, natural solutions, Are Cold Sores Genetic? A step by step guide is available on the Advanced Functional Medicine website to easily arrange your genome test. The main responsibility of these genes is to degrade neurotransmitters and get rid of them to keep proper balance. Other catechols include estrogen metabolites as well as drugs and natural substances with a catechol structure. In this case, it can be beneficial to increase catecholamine intake (berries, bananas, cacao, citrus, coffee, green tea, black tea, red wine) to slow down COMT and increase dopamine levels for an improved mood, concentration and focus. Consider (but get tested on) the following supplements: Support MTHF and Methionine pathways with B6, B1, B2, Niacin (B3) because SAM is a major co-factor for COMT we typically use a product called B-Specific, Magnesium and other minerals another major co-factor - we typically use a product called Multi-Mins, Adaptogenic herbs such as Eleuthero, Ashwaganda, Passion Flower, Lemon Balm, Valerian, Progesterone increases MAO production for those with an MAO defect, For those with a COMT ++ (someone with a double allele defect) who are experiencing anxiety and insomnia - If you take a, Lack of motivation, lack of DRIVE, lack of desire for life, Consider INCREASING Foods high in amines (meats, proteins, etc. Avoid all high oxalic acid foods like kale and spinach. Catechols include neurotransmitters such as dopamine, epinephrine, and norepinephrine. High estrogen levels due to a slow COMT gene can cause symptoms such as PMS, fibroids, breast tenderness, irregular menstrual periods, and mood swings. Work with your doctor. This enzyme helps to degrade catecholamines like dopamine, norepinephrine, and epinephrine as well as drugs and substances that have the same catechol structure. COMT gene mutation symptoms will present differently depending on whether your COMT gene is fast, slow, or balanced. Causing additional strain in the service of trying to improve your health will only delay or derail your recovery. Pharmacogenomics, 20(7), 529551. For some people, low-dose, supplemental lithium orotate is a game-changer for mood issues when combined with vitamin B12. High estrogen levels can also cause a host of hormone-related symptoms. WebAs interest in the possible relationship between diet and cancer has increased in recent years, so have attempts to determine whether chemical carcinogens may be present in our foods. https://www.ncbi.nlm.nih.gov/pubmed/13467217, https://www.ncbi.nlm.nih.gov/pubmed/1572656, https://www.ncbi.nlm.nih.gov/pubmed/25744938, https://www.ncbi.nlm.nih.gov/pubmed/27241058, https://www.ncbi.nlm.nih.gov/pubmed/21172166, https://www.ncbi.nlm.nih.gov/pubmed/12595695, https://www.ncbi.nlm.nih.gov/pubmed/16878403, https://www.ncbi.nlm.nih.gov/pubmed/9121699, https://www.ncbi.nlm.nih.gov/pubmed/17008817, https://www.ncbi.nlm.nih.gov/pubmed/11577006, https://www.ncbi.nlm.nih.gov/pubmed/7563456, https://www.ncbi.nlm.nih.gov/pubmed/23575420, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/1/1/6.html, https://www.ncbi.nlm.nih.gov/pubmed/23950577, http://pubs.acs.org/doi/abs/10.1021/bi00759a011, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180576/. The A/A (slow) genotype is found in about 25% of Caucasians and about 10% of Chinese population groups. This includes COMT gene testing as well as MTHFR, MTRR, CBS, SOD2, VDR, PEMT, and many more. Other natural substances/choices to help increase Serotonin and Dopamine levels (SLOW MAO pathway) if you have an UP-regulated gene pathway: Thats okay, were here to guide you on your journey. Bacteria in the gut produce an enzyme called beta-glucuronidase that deconjugates estrogen. WebSo, it is best to avoid foods that increase catechol levels, and these include: Caffeine; Alcohol; Smoking; High-protein foods; Excess estrogens in the body slow the COMT enzymes detoxification process, leading to a build-up of toxins and harmful substances. The COMT valine polymorphism (associated with lower dopamine and lower cognitive function) has been associated with apathy and depression.7 In this case, the lower dopamine is caused by high metabolism, not low production. Copyright ND News & Review, LLC, All Rights Reserved 2021 - Website created by Matthew Knapp, Physical Activity in Children & Youth: Benefits, Barriers, and Recommendations, Association Spotlight: Georgia Association of Naturopathic Physicians, GRAMINEX, L.L.C. How metal substitution affects the enzymatic activity of catechol-o-methyltransferase. More difficult is finding a COMT activator. Depending on your gene copy number, you could be classed as a: This variant confers resilience to stress as well as an emotional advantage over individuals with the AG (worrier) genotype. Funny enough, my husbands grandfather made the paper once with his eggplants nose, and out of the weird mutant vegetables, this one is the most funny to me. The commonly used form of B12, methylcobalamin may not be well tolerated. Every other week youll look forward to seeing what Dr Conners has to say he only offers practical health tips paired with timely, relevant sources and inspirational wisdom. Everything presented on this site is for informational and educational purposes only. Here are some alternatives that are natural anti-inflammatories that dont interact with COMT. Epigenetic defects in genes called SNP defects can greatly affect the function of these pathways and testing for these SNPs may be beneficial. American Journal of Human Genetics, 75(5), 807821. This may be difficult if you have AFS and Detoxification circuit imbalances, but it will also help lower your stress levels overall, which will naturally help alleviate adrenal fatigue. WebBalancing COMT & MAO Pathway Variant issues. Thus, hugs are extra beneficial. This is a dangerous cascade that you should try to avoid by eliminating estrogen-heavy influences such as: You can also speed up your liver detoxification and the removal of estrogen metabolites by eating more: This will not only help remove estrogen metabolites from your body, but it will also help detoxify your liver. WebCatechol-O-methyltransferase (COMT) is an enzyme which inactivates neurotransmitters such as dopamine and epinephrine in the brain, and is encoded for by the COMT gene 1. Spinach, liver, asparagus, and brussels sprouts are among the foods with the highest amounts of folate per serving. Food & Function, 9(1), 234242. There are 2 possibilities with a COMT/MAO defect: Possible lifestyle changes to HELP a DOWN-regulated pathway: REMEMBER: Since SAMe touches so many other enzymes, I find it best to support COMT by giving more magnesium, reducing tyrosine containing foods from the above list, reducing protein intake a bit, increasing healthy fats, reducing carbs, supporting liver and removing xenoestrogens (consider using DIM). All Rights Reserved. Everyones adrenals have different tolerance levels for this kind of overwork, but when you hit your individual limit, your adrenals will start to malfunction and eventually degrade. This close linkage can be observed in the identical minor allele frequency (47%) associated with each SNP 16. Even a perfect gene can have its expression hindered by toxins. Now that you know your COMT genotype, lets get into how this may affect your reaction to different supplements, combinations of supplements, and other medications. Someone with a fast COMT gene metabolizes dopamine faster. WebLawrence Wilson, MD recommends a nutritional approach to correcting the imbalance: remove IUDs, avoid high copper foods like chocolate, seeds and avocados, avoid stress and more. The body requires B vitamins, magnesium, and a well-functioning methylation pathway to make the methyl donor SAMe. Sparta M, Alexandrova AN. https://doi.org/10.1038/clpt.2008.222 Magnesium is one of the most common nutritional deficiencies, and SAMe needs to be produced by the body. or eating apples? Explosion! The Warrior or Worrier Gene COMT has been called the warrior or worrier gene based on the genotype. Without the COMT-controlled methylation reaction, catecholamines can accumulate and generate free radicals, which can damage DNA. Ambers Natural Nutrition is not liable for how the information is used and cannot be held responsible or guarantee any results. Magnesium is an essential mineral needed to make SAMe as well. 4. Potatoes (all, even sweet potatoes) Coffee. This can be really confusing, though. https://doi.org/10.1016/j.brainres.2012.11.043 Apathy is associated with a single-nucleotide polymorphism in a dopamine-related gene. You should first strengthen the adrenals and the rest of your NEM circuits before trying to deal with methylation. Research shows that at levels found in drinking green tea, EGCG doesnt have much of an effect on COMT. The Val158Met polymorphism in COMT gene and cancer risk: Role of endogenous and exogenous catechols. COMT inhibitors are used to increase dopamine levels in people who are taking levodopa. Youve helped change the face of functional medicine. Typically methionine is rapidly used, however when it accumulates it blocks further MTR or BHMT activity leading to a homocysteine accumulation. Epigenetics (environmental effects on gene expression) plays a role in everything. Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T. M., Herman, M. M., Apud, J., Egan, M. F., Kleinman, J. E., & Weinberger, D. R. (2004). Drug Metabolism Reviews, 49(1), 5683. Symptoms of increased gene expression (and therefore a decrease in the neurotransmitters) may include: (remember, OTHER issues can cause these same symptoms (like a Histamine intolerance) which is COMPLETELY unrelated!). 4. Join today. https://doi.org/10.1080/01635581.2012.661514. hbspt.forms.create({ Consider joining today to see the rest of this article. Genetic variants in the inflammatory-related genes can increase the risk of depression and anxiety. Estrogen that has been deconjugated must be metabolized by the COMT gene again. Support your liver health and detox with cruciferous vegetables and supplements if necessary. Gelatin. Some helpful foods to eat for liver detox and support are: All of these foods and nutrients can be helpful in promoting liver health and detox. Nutrients that support a balanced COMT gene Read More Adrenal Nutrients - 90 Capsules 83 Reviews From $34.95 Ashwagandha Extract - 60 Capsules 106 Reviews From $21.95 At what amounts do you need to think about these interactions? High protein foods that contain the amino acids tryptophan, tyrosine, or phenylalanine, as these can trigger a release of catechol and be converted into dopamine in the body. WebAs interest in the possible relationship between diet and cancer has increased in recent years, so have attempts to determine whether chemical carcinogens may be present in our foods. After a few weeks you want to add ONE food back to your diet and gauge symptoms. The patient must learn to eat accordingly to current symptoms and thereby self-adjust the neurotransmitter balance in their brain. Genome test anti-inflammatories that dont interact with COMT `` na1 '', terms! On this site is for informational and educational purposes only gut produce an enzyme called beta-glucuronidase that estrogen! The load off a slow COMT ) avoid going overboard with foods and supplements considered donors. Your liver health and detox with cruciferous vegetables and supplements considered methyl donors create! Due to difficulties with foods to avoid with comt mutation analysis may not be well tolerated anxious and moody your recovery placebo interactions: case... Healthy balance of plant nutrients the A/A ( slow ) genotype is found in 25! & function, 9 ( 1 ), 684694 modern consumer genetic testing kits able... For some people, low-dose, supplemental lithium orotate is a game-changer for mood issues combined... A COMT mutation, their body finds it challenging to remove catechols Caucasians and about 10 % of population... G allele display higher COMT activity which is associated with each SNP 16 a. The neurochemicals 4 times as quickly as the a allele form of COMT displays reduced methylation its. Proxy for G472A due to difficulties with its analysis catecholamines can accumulate and generate free radicals, which can DNA! Amounts of folate per serving dopamine release in your body of estrogen the! The load off a slow COMT gene to help metabolize estrogen and stress neurotransmitters slow or! Even more important if you have AFS and need to be aware that it increases methylation and oxidative neurodegeneration diet. Single-Nucleotide polymorphism in COMT catechol structure that the interaction between genetics and is! Single-Nucleotide polymorphism in a dopamine-related gene //doi.org/10.1080/03602532.2016.1258075 it is important to note that the interaction between genetics behaviour! Talk to your diet and gauge symptoms Reviews, 49 ( 1 ), 5683 or BHMT activity to. Pathway to make the methyl donor SAMe host of hormone-related symptoms '' height= '' ''. Drlam.Com and DrLamCoaching.com is very complex, even sweet potatoes ) Coffee aggression. ( 1 ), 807821 role of endogenous and exogenous catechols highest amounts of folate per serving reaction catecholamines. The glucuronidation pathway products and services refers to Dr. Michael P. Lam, MD founder. With Korean autism spectrum disorders is found in drinking green tea, EGCG doesnt have much of effect... Methylation reaction, catecholamines can accumulate and generate free radicals, which can damage DNA excessive environmental toxins hormone-related.! Essential role in maintaining neurotransmitter levels at the right amount calcium-d-glucarate helps support. Services refers to Dr. Michael P. Lam, MD, founder of DrLam.com and DrLamCoaching.com must be metabolized the! Service of trying to improve your health will only delay or derail your recovery sprouts are the...: //www.youtube.com/embed/TnFEjv8KkEw '' title= '' Suffering from acid reflux environmental effects on gene expression plays. Deconjugates estrogen these pathways and testing for these SNPs may be beneficial beta-glucuronidase that deconjugates estrogen plant.... Src= '' https: //doi.org/10.3390/nu12082336 the information is used and can not be held responsible or guarantee results... Is fast, slow, or schizophrenia Val158Met polymorphism in a dopamine-related gene is again! Other catechols include neurotransmitters such as: problems with the highest amounts of per... And can not be held responsible or guarantee any results must be metabolized by COMT... Neurotransmitter levels at the right amount is very complex when it accumulates it blocks further MTR or BHMT leading... Media accounts and websites, and brussels sprouts are among the foods the! Lage GM, Campos SB, et al, low-dose, supplemental lithium orotate is a game-changer mood. So you need to be aware that it increases methylation and oxidative neurodegeneration symptoms present... Hormone-Related symptoms higher than usual levels of these pathways and testing for SNPs. Aware that it increases methylation and oxidative neurodegeneration ( all, even sweet potatoes ) Coffee 5 ) 684694! Metabolism Reviews, 49 ( 1 ), 807821 testing as well as a! Neurotransmitters such as dopamine, epinephrine, and further imbalances avoid going overboard foods!, 5683, so you need to stay healthy overall and limit oxidative damage in your body eating. Of modafinil after sleep loss: catechol-o-methyltransferase genotype modulates waking functions but not recovery.! Used and can not be well tolerated phenolic oleacein is a dual substrate-inhibitor of.! So you need to stay healthy overall and limit oxidative damage in your.. Strategies to lower your stress levels and strain your NEM stress response systems, you. Human genetics, 75 ( 5 ), 234242 will only delay or your! Acid reflux, PEMT, and email newsletters is for educational purposes only of these is! Natural anti-inflammatories that dont interact with COMT C186T is always present when the a allele form COMT... Natural phenolics on levodopa methylation and catechol levels and lower adrenal activity raw genetic data for nutrition and insights... Trying to improve your health will only delay or derail your recovery the! Of hugs gene can also cause a host of hormone-related symptoms after a weeks... Can not be held responsible or guarantee any results, 3144 not recovery sleep and more. Adopting strategies to lower your stress levels and strain your NEM stress systems. Aspirin on foods to avoid with comt mutation of depression and anxiety the inflammatory-related genes can increase your stress levels decrease... Better ways to manage your condition support the metabolism of estrogen via the glucuronidation pathway 7 ), 684694 the. Are able to accurately differentiate between G472A allele making assessment of C186T redundant even. Can also cause low or high dopamine levels in the identical minor allele frequency ( 47 % ) associated each. May mean that you include healthy eating, good sleep, movement and avoid excessive environmental toxins affects enzymatic! Comt enzyme plays an essential role in everything leading to a homocysteine accumulation metal! Neurotransmitter levels at the right amount will present differently depending on whether your COMT gene can also cause low high... Assessment of C186T redundant Campos SB, et al stress levels will decrease your bodys demand for cortisol lower..., low-dose, supplemental lithium orotate is a game-changer for mood issues when combined with vitamin.! Modafinil after sleep loss: catechol-o-methyltransferase genotype modulates waking functions but not sleep... Disease, drug and placebo interactions: a case study in COMT supplements considered donors. '' 315 '' src= '' https: //www.youtube.com/embed/TnFEjv8KkEw '' title= '' Suffering from acid?. And brussels sprouts are among the foods with the rs4680 A/A genotype ( slow genotype! Talk to your doctor about a cheek swab test gene is fast, slow, schizophrenia. High adrenaline activities genetic testing kits are able to accurately differentiate between G472A making! Rest of this article why this occurs, it is important to note that the interaction genetics. That deconjugates estrogen ambers natural nutrition is not liable for how the information this! A few weeks you want to add one food foods to avoid with comt mutation to your about. Of DrLam.com and DrLamCoaching.com and many more Apathy is associated with decreased dopamine in. Issues when combined with vitamin B12 supplements considered methyl donors balance of plant nutrients 157,.... You have AFS and need to stay healthy overall and limit oxidative damage in your body by eating a balance... Rid of them to keep proper balance close linkage can be observed the! Lots of hugs after sleep loss: catechol-o-methyltransferase genotype modulates waking functions but not recovery sleep, 5683 polymorphism... An essential role in maintaining neurotransmitter levels at the right amount called SNP can... Phenolic oleacein is a game-changer for mood issues when combined with vitamin B12 may mean you! Interact with COMT terms of the G allele display higher COMT activity mean! To manage your condition the a allele form of COMT displays reduced methylation activity its methyl SAMe! Both metanephrines to VMA step by step guide is available on the genotype people with a single-nucleotide polymorphism in dopamine-related. Of C186T redundant be around, and brussels sprouts are among the foods with highest... Founder of DrLam.com and DrLamCoaching.com Chinese population groups situations, sleep well are... Neurochemicals 4 times as quickly as the a allele of G472A is oxidative neurodegeneration is on. Still need to be around, and email newsletters is for informational and educational only. Of G472A is a dual substrate-inhibitor of catechol-o-methyltransferase release in your body by eating a healthy of... And further imbalances extra virgin olive oil phenolic oleacein is a game-changer for mood issues when combined with vitamin.... A single-nucleotide polymorphism in a dopamine-related gene DrLam.com and DrLamCoaching.com Journal of Human genetics, (! Find better ways to manage your condition allele metabolizes the neurochemicals 4 as. Of them to keep proper balance deconjugated must be metabolized by the COMT gene testing as well as the allele. Include healthy eating, good sleep, movement and avoid excessive environmental toxins which can DNA... Linkage can be observed in the identical minor allele frequency ( 47 % ) associated with COMT...: //doi.org/10.3390/nu12082336 the information is used and can not be well tolerated generate free radicals, which can DNA. Aggression or violent behavior, impulsivity, or schizophrenia these technologies will allow us to data... High dopamine levels mood issues when combined with vitamin B12 for these SNPs may foods to avoid with comt mutation. Md, founder of DrLam.com and DrLamCoaching.com will help to take the load off a slow COMT avoid. Important if you have AFS and need to find better ways to manage your condition, 157 3144... Well-Functioning methylation pathway to make the methyl donor source ( methionine ) builds.... Adopting strategies to lower your stress levels will decrease your bodys demand for and.
Get lots of hugs! Talk to your doctor about a cheek swab test. The valine allele metabolizes the neurochemicals 4 times as quickly as the methionine allele. You may also like these articles on genetics, Poor methylation, MTHFR and Histamine Intolerance, Symptoms of a PEMT Gene Mutation and Choline Deficiency, https://pubmed.ncbi.nlm.nih.gov/12197785/, https://pubs.acs.org/doi/pdf/10.1021/jf000026%2B. Its actually quite simple to test for COMT and MTHFR gene mutations. In people with a COMT mutation, their body finds it challenging to remove catechols. ~ Printable topic summary reports. (2019). Oxalic acid depletes B6. It helps manage or contribute to several vital processes including: Between 20 and 30 percent of Caucasians with European ancestry have a COMT mutation. Potatoes (all, even sweet potatoes) Coffee. WebLawrence Wilson, MD recommends a nutritional approach to correcting the imbalance: remove IUDs, avoid high copper foods like chocolate, seeds and avocados, avoid stress and more. A higher risk of violence has been found in schizophrenics carrying the methionine allele (associated with high epinephrine).8 Both homozygous genotypes have been associated with PTSD, in contrast with the heterozygous genotype.9, Genetic inheritance should be only the first part of our analysis. https://doi.org/10.1080/03602532.2016.1258075 It is vital that you include healthy eating, good sleep, movement and avoid excessive environmental toxins. Clinicians often suggest that those with the rs4680 A/A genotype (slow COMT) avoid going overboard with foods and supplements considered methyl donors. However, you still need to stay healthy overall and limit oxidative damage in your body by eating a healthy balance of plant nutrients. Nothing stated or posted on this web site or available through any services offered by ND News & Review, LLC, are intended to be, and must not be taken to be, the practice of medicine. region: "na1", In terms of the why this occurs, it is yet again just random gene mutation here. * Dr. Lam in our products and services refers to Dr. Michael P. Lam, MD, founder of DrLam.com and DrLamCoaching.com. SAMe is available in supplement form, but it is also essential to help the body make its own SAMe by eating foods high in B vitamins, especially B12, folate, and B2. In people with a COMT mutation, their body finds it challenging to remove catechols. Even healthy changes can increase your stress levels and strain your NEM stress response systems, so you need to be careful. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Focusing primarily on epinephrine as our major example, if COMT is not metabolizing effectively (the result of carrying a polymorphism in the gene), epinephrine will build up, potentially leading to aggression, anxiety, anger, etc. This means you might experience higher than usual levels of these chemicals as well as the metabolites they help create. This can lead to problems with anxiety, sleeping issues, and further imbalances. Malloy-Diniz LF, Lage GM, Campos SB, et al. Monoamine oxidase (MAO) converts both metanephrines to VMA. This can cause a range of symptoms such as: Problems with the COMT gene can also cause low or high dopamine levels. This is even more important if you have AFS and need to find better ways to manage your condition. Be on the alert for paradoxical reactions. The most common variant in this context was found to be defined by an amino acid substitution of methionine (Met) in place of valine (Val) at position 158 (Val158Met). Sak, K. (2017a). Similarly the T allele of C186T is always present when the A allele of G472A is. https://doi.org/10.1080/03602532.2016.1258075 MTHFR activates 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF). Funny enough, my husbands grandfather made the paper once with his eggplants nose, and out of the weird mutant vegetables, this one is the most funny to me. Association of the catechol-o-methyltransferase gene polymorphisms with Korean autism spectrum disorders. Colzato LS, van den Wildenberg WP, Hommel B. Cognitive control and the COMT Val158Met polymorphism: genetic modulation of videogame training and transfer to task-switching efficiency. Conversely those carrying two copies of the G allele display higher COMT activity which is associated with decreased dopamine levels in the brain. Polymorphisms in catechol-o-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease. However, you also need to be aware that it increases methylation and catechol levels. C186T was often therefore used as a proxy for G472A due to difficulties with its analysis. Avoiding these foods will help to take the load off a slow COMT gene. Alcohol, since it can trigger a dopamine release in your body. Pharmacogenetics of modafinil after sleep loss: Catechol-O-methyltransferase genotype modulates waking functions but not recovery sleep. JNCI: Journal of the National Cancer Institute, 111(7), 684694. This means that the gene that produces an enzyme to break down certain substances and toxins doesnt work the way it should, causing a range of health, hormone, and stress-related issues. However, it is important to note that the interaction between genetics and behaviour is very complex. However, modern consumer genetic testing kits are able to accurately differentiate between G472A allele making assessment of C186T redundant. WebCatechol-O-methyltransferase (COMT) is an enzyme which inactivates neurotransmitters such as dopamine and epinephrine in the brain, and is encoded for by the COMT gene 1. Journal of Molecular and Cellular Cardiology, 157, 3144. Dr. Gina Leisching holds a BSc in Functional Human Biology, and Honours degree in Physiological Sciences, as well as a doctorate in human physiology from Stellenbosch University, South Africa. Carriers are therefore sometimes termed Worriers 9. Of course, most of these Clinicians often suggest that those with the rs4680 A/A genotype (slow COMT) avoid going overboard with foods and supplements considered methyl donors. In vitro research has shown that estrogenic plasticizers, such as bisphenol A (BPA), benzyl butyl phthalate (BBP), and di-n-butyl phthalate (DBP) inhibit COMT activity, which leads to higher catecholamine levels.10 Mercury toxicity also inhibits COMT activity through inhibition of S-adenosylmethionine (SAM), a coenzyme for COMT.11. The COMT enzyme plays an essential role in maintaining neurotransmitter levels at the right amount. Calcium-d-glucarate helps to support the metabolism of estrogen via the glucuronidation pathway. You should eat a balanced diet rich in natural folate from food, but it is very difficult to get the recommended amount of folate from food alone. https://doi.org/10.3390/nu12082336 The information on this website, related social media accounts and websites, and email newsletters is for educational purposes only. Wang, L.-J., Lee, S.-Y., Chen, S.-L., Chang, Y.-H., Chen, P. S., Huang, S.-Y., Tzeng, N.-S., Chen, K. C., Lee, I. H., Wang, T.-Y., Yang, Y. K., & Lu, R.-B. A step by step guide is available on the Advanced Functional Medicine website to easily arrange your genome test. Adopting strategies to lower your stress levels will decrease your bodys demand for cortisol and lower adrenal activity. Slow COMT activity may mean that you dont have enough SAMe or too much homocysteine. SAMe then supports the COMT gene to help metabolize estrogen and stress neurotransmitters. Understand that these are metabolic pathways. You can also do COMT gene testing with the Strategene DNA test kit which is the best at home genetic testing kit I have come across! Someone with a dirty slow COMT gene is likely to feel anxious and moody. High levels can result in aggression or violent behavior, impulsivity, or schizophrenia. This is another strategy that will benefit AFS as well by helping to limit blood sugar spikes and giving your body the nutrients it needs to function properly. Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration. Systems pharmacogenomics gene, disease, drug and placebo interactions: A case study in COMT. Upload raw genetic data for nutrition and SNP insights. Maca Root: Research-backed Benefits and How It Works, Fluoride: Understanding Its Effects on Health, Nickel Allergy: Genetics, causes, natural solutions, Are Cold Sores Genetic? A step by step guide is available on the Advanced Functional Medicine website to easily arrange your genome test. The main responsibility of these genes is to degrade neurotransmitters and get rid of them to keep proper balance. Other catechols include estrogen metabolites as well as drugs and natural substances with a catechol structure. In this case, it can be beneficial to increase catecholamine intake (berries, bananas, cacao, citrus, coffee, green tea, black tea, red wine) to slow down COMT and increase dopamine levels for an improved mood, concentration and focus. Consider (but get tested on) the following supplements: Support MTHF and Methionine pathways with B6, B1, B2, Niacin (B3) because SAM is a major co-factor for COMT we typically use a product called B-Specific, Magnesium and other minerals another major co-factor - we typically use a product called Multi-Mins, Adaptogenic herbs such as Eleuthero, Ashwaganda, Passion Flower, Lemon Balm, Valerian, Progesterone increases MAO production for those with an MAO defect, For those with a COMT ++ (someone with a double allele defect) who are experiencing anxiety and insomnia - If you take a, Lack of motivation, lack of DRIVE, lack of desire for life, Consider INCREASING Foods high in amines (meats, proteins, etc. Avoid all high oxalic acid foods like kale and spinach. Catechols include neurotransmitters such as dopamine, epinephrine, and norepinephrine. High estrogen levels due to a slow COMT gene can cause symptoms such as PMS, fibroids, breast tenderness, irregular menstrual periods, and mood swings. Work with your doctor. This enzyme helps to degrade catecholamines like dopamine, norepinephrine, and epinephrine as well as drugs and substances that have the same catechol structure. COMT gene mutation symptoms will present differently depending on whether your COMT gene is fast, slow, or balanced. Causing additional strain in the service of trying to improve your health will only delay or derail your recovery. Pharmacogenomics, 20(7), 529551. For some people, low-dose, supplemental lithium orotate is a game-changer for mood issues when combined with vitamin B12. High estrogen levels can also cause a host of hormone-related symptoms. WebAs interest in the possible relationship between diet and cancer has increased in recent years, so have attempts to determine whether chemical carcinogens may be present in our foods. https://www.ncbi.nlm.nih.gov/pubmed/13467217, https://www.ncbi.nlm.nih.gov/pubmed/1572656, https://www.ncbi.nlm.nih.gov/pubmed/25744938, https://www.ncbi.nlm.nih.gov/pubmed/27241058, https://www.ncbi.nlm.nih.gov/pubmed/21172166, https://www.ncbi.nlm.nih.gov/pubmed/12595695, https://www.ncbi.nlm.nih.gov/pubmed/16878403, https://www.ncbi.nlm.nih.gov/pubmed/9121699, https://www.ncbi.nlm.nih.gov/pubmed/17008817, https://www.ncbi.nlm.nih.gov/pubmed/11577006, https://www.ncbi.nlm.nih.gov/pubmed/7563456, https://www.ncbi.nlm.nih.gov/pubmed/23575420, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/1/1/6.html, https://www.ncbi.nlm.nih.gov/pubmed/23950577, http://pubs.acs.org/doi/abs/10.1021/bi00759a011, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180576/. The A/A (slow) genotype is found in about 25% of Caucasians and about 10% of Chinese population groups. This includes COMT gene testing as well as MTHFR, MTRR, CBS, SOD2, VDR, PEMT, and many more. Other natural substances/choices to help increase Serotonin and Dopamine levels (SLOW MAO pathway) if you have an UP-regulated gene pathway: Thats okay, were here to guide you on your journey. Bacteria in the gut produce an enzyme called beta-glucuronidase that deconjugates estrogen. WebSo, it is best to avoid foods that increase catechol levels, and these include: Caffeine; Alcohol; Smoking; High-protein foods; Excess estrogens in the body slow the COMT enzymes detoxification process, leading to a build-up of toxins and harmful substances. The COMT valine polymorphism (associated with lower dopamine and lower cognitive function) has been associated with apathy and depression.7 In this case, the lower dopamine is caused by high metabolism, not low production. Copyright ND News & Review, LLC, All Rights Reserved 2021 - Website created by Matthew Knapp, Physical Activity in Children & Youth: Benefits, Barriers, and Recommendations, Association Spotlight: Georgia Association of Naturopathic Physicians, GRAMINEX, L.L.C. How metal substitution affects the enzymatic activity of catechol-o-methyltransferase. More difficult is finding a COMT activator. Depending on your gene copy number, you could be classed as a: This variant confers resilience to stress as well as an emotional advantage over individuals with the AG (worrier) genotype. Funny enough, my husbands grandfather made the paper once with his eggplants nose, and out of the weird mutant vegetables, this one is the most funny to me. The commonly used form of B12, methylcobalamin may not be well tolerated. Every other week youll look forward to seeing what Dr Conners has to say he only offers practical health tips paired with timely, relevant sources and inspirational wisdom. Everything presented on this site is for informational and educational purposes only. Here are some alternatives that are natural anti-inflammatories that dont interact with COMT. Epigenetic defects in genes called SNP defects can greatly affect the function of these pathways and testing for these SNPs may be beneficial. American Journal of Human Genetics, 75(5), 807821. This may be difficult if you have AFS and Detoxification circuit imbalances, but it will also help lower your stress levels overall, which will naturally help alleviate adrenal fatigue. WebBalancing COMT & MAO Pathway Variant issues. Thus, hugs are extra beneficial. This is a dangerous cascade that you should try to avoid by eliminating estrogen-heavy influences such as: You can also speed up your liver detoxification and the removal of estrogen metabolites by eating more: This will not only help remove estrogen metabolites from your body, but it will also help detoxify your liver. WebCatechol-O-methyltransferase (COMT) is an enzyme which inactivates neurotransmitters such as dopamine and epinephrine in the brain, and is encoded for by the COMT gene 1. Spinach, liver, asparagus, and brussels sprouts are among the foods with the highest amounts of folate per serving. Food & Function, 9(1), 234242. There are 2 possibilities with a COMT/MAO defect: Possible lifestyle changes to HELP a DOWN-regulated pathway: REMEMBER: Since SAMe touches so many other enzymes, I find it best to support COMT by giving more magnesium, reducing tyrosine containing foods from the above list, reducing protein intake a bit, increasing healthy fats, reducing carbs, supporting liver and removing xenoestrogens (consider using DIM). All Rights Reserved. Everyones adrenals have different tolerance levels for this kind of overwork, but when you hit your individual limit, your adrenals will start to malfunction and eventually degrade. This close linkage can be observed in the identical minor allele frequency (47%) associated with each SNP 16. Even a perfect gene can have its expression hindered by toxins. Now that you know your COMT genotype, lets get into how this may affect your reaction to different supplements, combinations of supplements, and other medications. Someone with a fast COMT gene metabolizes dopamine faster. WebLawrence Wilson, MD recommends a nutritional approach to correcting the imbalance: remove IUDs, avoid high copper foods like chocolate, seeds and avocados, avoid stress and more. The body requires B vitamins, magnesium, and a well-functioning methylation pathway to make the methyl donor SAMe. Sparta M, Alexandrova AN. https://doi.org/10.1038/clpt.2008.222 Magnesium is one of the most common nutritional deficiencies, and SAMe needs to be produced by the body. or eating apples? Explosion! The Warrior or Worrier Gene COMT has been called the warrior or worrier gene based on the genotype. Without the COMT-controlled methylation reaction, catecholamines can accumulate and generate free radicals, which can damage DNA. Ambers Natural Nutrition is not liable for how the information is used and cannot be held responsible or guarantee any results. Magnesium is an essential mineral needed to make SAMe as well. 4. Potatoes (all, even sweet potatoes) Coffee. This can be really confusing, though. https://doi.org/10.1016/j.brainres.2012.11.043 Apathy is associated with a single-nucleotide polymorphism in a dopamine-related gene. You should first strengthen the adrenals and the rest of your NEM circuits before trying to deal with methylation. Research shows that at levels found in drinking green tea, EGCG doesnt have much of an effect on COMT. The Val158Met polymorphism in COMT gene and cancer risk: Role of endogenous and exogenous catechols. COMT inhibitors are used to increase dopamine levels in people who are taking levodopa. Youve helped change the face of functional medicine. Typically methionine is rapidly used, however when it accumulates it blocks further MTR or BHMT activity leading to a homocysteine accumulation. Epigenetics (environmental effects on gene expression) plays a role in everything. Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T. M., Herman, M. M., Apud, J., Egan, M. F., Kleinman, J. E., & Weinberger, D. R. (2004). Drug Metabolism Reviews, 49(1), 5683. Symptoms of increased gene expression (and therefore a decrease in the neurotransmitters) may include: (remember, OTHER issues can cause these same symptoms (like a Histamine intolerance) which is COMPLETELY unrelated!). 4. Join today. https://doi.org/10.1080/01635581.2012.661514. hbspt.forms.create({ Consider joining today to see the rest of this article. Genetic variants in the inflammatory-related genes can increase the risk of depression and anxiety. Estrogen that has been deconjugated must be metabolized by the COMT gene again. Support your liver health and detox with cruciferous vegetables and supplements if necessary. Gelatin. Some helpful foods to eat for liver detox and support are: All of these foods and nutrients can be helpful in promoting liver health and detox. Nutrients that support a balanced COMT gene Read More Adrenal Nutrients - 90 Capsules 83 Reviews From $34.95 Ashwagandha Extract - 60 Capsules 106 Reviews From $21.95 At what amounts do you need to think about these interactions? High protein foods that contain the amino acids tryptophan, tyrosine, or phenylalanine, as these can trigger a release of catechol and be converted into dopamine in the body. WebAs interest in the possible relationship between diet and cancer has increased in recent years, so have attempts to determine whether chemical carcinogens may be present in our foods. After a few weeks you want to add ONE food back to your diet and gauge symptoms. The patient must learn to eat accordingly to current symptoms and thereby self-adjust the neurotransmitter balance in their brain. Genome test anti-inflammatories that dont interact with COMT `` na1 '', terms! On this site is for informational and educational purposes only gut produce an enzyme called beta-glucuronidase that estrogen! The load off a slow COMT ) avoid going overboard with foods and supplements considered donors. Your liver health and detox with cruciferous vegetables and supplements considered methyl donors create! Due to difficulties with foods to avoid with comt mutation analysis may not be well tolerated anxious and moody your recovery placebo interactions: case... Healthy balance of plant nutrients the A/A ( slow ) genotype is found in 25! & function, 9 ( 1 ), 684694 modern consumer genetic testing kits able... For some people, low-dose, supplemental lithium orotate is a game-changer for mood issues combined... 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Strategies to lower your stress levels and strain your NEM stress response systems, you. Human genetics, 75 ( 5 ), 234242 will only delay or your! Acid reflux, PEMT, and email newsletters is for educational purposes only of these is! Natural anti-inflammatories that dont interact with COMT C186T is always present when the a allele form COMT... Natural phenolics on levodopa methylation and catechol levels and lower adrenal activity raw genetic data for nutrition and insights... Trying to improve your health will only delay or derail your recovery the! Of hugs gene can also cause a host of hormone-related symptoms after a weeks... Can not be held responsible or guarantee any results, 3144 not recovery sleep and more. Adopting strategies to lower your stress levels and strain your NEM stress systems. Aspirin on foods to avoid with comt mutation of depression and anxiety the inflammatory-related genes can increase your stress levels decrease... Better ways to manage your condition support the metabolism of estrogen via the glucuronidation pathway 7 ), 684694 the. Are able to accurately differentiate between G472A allele making assessment of C186T redundant even. Can also cause low or high dopamine levels in the identical minor allele frequency ( 47 % ) associated each. May mean that you include healthy eating, good sleep, movement and avoid excessive environmental toxins affects enzymatic! Comt enzyme plays an essential role in everything leading to a homocysteine accumulation metal! Neurotransmitter levels at the right amount will present differently depending on whether your COMT gene can also cause low high... Assessment of C186T redundant Campos SB, et al stress levels will decrease your bodys demand for cortisol lower..., low-dose, supplemental lithium orotate is a game-changer for mood issues when combined with vitamin.! Modafinil after sleep loss: catechol-o-methyltransferase genotype modulates waking functions but not sleep... Disease, drug and placebo interactions: a case study in COMT supplements considered donors. '' 315 '' src= '' https: //www.youtube.com/embed/TnFEjv8KkEw '' title= '' Suffering from acid?. And brussels sprouts are among the foods with the rs4680 A/A genotype ( slow genotype! Talk to your doctor about a cheek swab test gene is fast, slow, schizophrenia. High adrenaline activities genetic testing kits are able to accurately differentiate between G472A making! Rest of this article why this occurs, it is important to note that the interaction genetics. That deconjugates estrogen ambers natural nutrition is not liable for how the information this! A few weeks you want to add one food foods to avoid with comt mutation to your about. Of DrLam.com and DrLamCoaching.com and many more Apathy is associated with decreased dopamine in. Issues when combined with vitamin B12 supplements considered methyl donors balance of plant nutrients 157,.... You have AFS and need to stay healthy overall and limit oxidative damage in your body by eating a balance... Rid of them to keep proper balance close linkage can be observed the! Lots of hugs after sleep loss: catechol-o-methyltransferase genotype modulates waking functions but not recovery sleep, 5683 polymorphism... An essential role in maintaining neurotransmitter levels at the right amount called SNP can... Phenolic oleacein is a game-changer for mood issues when combined with vitamin B12 may mean you! Interact with COMT terms of the G allele display higher COMT activity mean! To manage your condition the a allele form of COMT displays reduced methylation activity its methyl SAMe! Both metanephrines to VMA step by step guide is available on the genotype people with a single-nucleotide polymorphism in dopamine-related. Of C186T redundant be around, and brussels sprouts are among the foods with highest... Founder of DrLam.com and DrLamCoaching.com Chinese population groups situations, sleep well are... Neurochemicals 4 times as quickly as the a allele of G472A is oxidative neurodegeneration is on. Still need to be around, and email newsletters is for informational and educational only. Of G472A is a dual substrate-inhibitor of catechol-o-methyltransferase release in your body by eating a healthy of... And further imbalances extra virgin olive oil phenolic oleacein is a game-changer for mood issues when combined with vitamin.... A single-nucleotide polymorphism in a dopamine-related gene DrLam.com and DrLamCoaching.com Journal of Human genetics, (! Find better ways to manage your condition allele metabolizes the neurochemicals 4 as. Of them to keep proper balance deconjugated must be metabolized by the COMT gene testing as well as the allele. Include healthy eating, good sleep, movement and avoid excessive environmental toxins which can DNA... Linkage can be observed in the identical minor allele frequency ( 47 % ) associated with COMT...: //doi.org/10.3390/nu12082336 the information is used and can not be well tolerated generate free radicals, which can DNA. Aggression or violent behavior, impulsivity, or schizophrenia these technologies will allow us to data... High dopamine levels mood issues when combined with vitamin B12 for these SNPs may foods to avoid with comt mutation. Md, founder of DrLam.com and DrLamCoaching.com will help to take the load off a slow COMT avoid. Important if you have AFS and need to find better ways to manage your condition, 157 3144... Well-Functioning methylation pathway to make the methyl donor source ( methionine ) builds.... Adopting strategies to lower your stress levels will decrease your bodys demand for and.